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There are over 200 signs and symptoms of celiac disease. These include both gastrointestinal and systemic presentations and vary highly from patient to patient, making diagnosis challenging. It is important to understand the various presentations of celiac disease to provide the best care for patients and appropriately treat related symptoms.

Ongoing research continues to unveil the complex ways in which the gut microbiota play a role in IBS onset and symptoms. While there is no single ideal composition of gut microbiota that defines a “healthy” composition, there are general strategies that can support a strong and robust Gut-Brain-Microbiota Axis.

The connection between the brain and the gut has long been recognized and, more recently, research has shed light on the nuanced mechanisms that govern this gut-brain communication and the crucial role played by gut microbiota. These findings provide valuable insights into communication pathways, their role in the pathophysiology of IBS, and implications for symptom management.

Celiac disease is a complex immune-mediated disease, triggered by the consumption of gluten in those with a genetic predisposition. Recent studies have highlighted the potential role of gut microbiota in the pathogenesis of celiac disease.

The objective of a recent study was to evaluate the structural and inflammatory features of NCWS compared to controls and celiac disease with milder enteropathy, since the histological changes induced by gluten in the duodenal mucosa of patients with NCWS is not well defined.

While the worldwide prevalence of celiac disease is 1%, its prevalence rises significantly among patients with concurrent type 1 diabetes mellitus (T1DM). Both celiac disease and T1DM are autoimmune disorders and require careful and lifelong management to avoid long-term health consequences.

While categorized as a digestive disorder, Irritable Bowel Syndrome (IBS) affects far more than the digestive tract. The most common symptoms of IBS include abdominal pain, bloating, constipation, and diarrhea, all of which not only cause physical discomfort, but also have a significant impact on a quality of life and mental health.

People with celiac disease often experience a long journey before being diagnosed with celiac disease. Delays in diagnosis prevent treatment of the symptoms and leads to significant quality of life disruption. A recent survey of people with celiac disease and their relatives examined the experiences that patients had on their way to diagnosis and provided insights as to how their situation could have been improved.

While strides have been made in recent years, accurate and timely diagnosis of celiac disease remains a challenge. Diagnosis is a multi-step process that includes clinical history, serology, histology, and symptom improvement and antibody response following transition to a gluten-free diet.