1. Dr.Schär Institute
  2. Dr. Schär Institute
  3. Bibliografía


Área de expertos
¿Es un profesional de la salud que trabaja con los trastornos relacionados con el gluten y el SII?
  1. Ludvigsson JF. Murray JA. Epidemiology of Celiac disease. In: Buchman AL (ed). Celiac disease. Gastroenterol Clin N Am 2019; 48: 1-18.
  2. Hujoel IA, Reilly NR. Rubio-Tapia A. Celiac disease: Clinical Features and diagnosis. In: Buchman AL (ed). Celiac disease. Gastroenterol Clin N Am 2019; 48:19-38
  3. Grupo de trabajo del Protocolo para el diagnóstico precoz de la enfermedad celiaca. Protocolo de Diagnóstico Precoz de la enfermedad celiaca. Ministerio de Sanidad, Servicios Sociales e Igualdad. Servicio de Evaluación del Servicio Canario de Salud (SESCS); 2018
  4. Fernández-Bañares F, Arau B, Dieli-Crimi R, Rosinach M, Nuñez C, Esteve M. Systematic Review and Meta-analysis Show 3% of Patients With Celiac Disease in Spain to be Negative for HLA-DQ2.5 and HLA-DQ8. Clin Gastroenterol Hepatol. 2017;15:594-6
  5. Catassi C, Fasano A. Celiac disease diagnosis: simple rules are better than complicated algorithms. Am J Med 2010: 123: 691–3.
  6. Aziz I, Evans KE, Hopper AD, Smillie DM, Sanders DS. A prospective study into the aetiology of lymphocytic duodenosis. Aliment Pharmacol Ther 2010; 32: 1392–7.
  7. Aziz I, Peerally MF, Barnes JH, Kandasamy V, Whiteley JC, Partridge D et al. The clinical and phenotypical assessment of seronegative villous atrophy; a prospective UK centre experience evaluating 200 adult cases over a 15-year period (2000-2015). Gut. 2017;66:1563-72.
  8. Sergi C, Shen F, Bouma G.Intraepithelial lymphocytes, scores, mimickers and challenges in diagnosing gluten-sensitive enteropathy (celiac disease). World J Gastroenterol. 2017;28;23:573-89
  9. Rosinach M, Esteve M, González C, Temino R, Mariné M, et al. Lymphocytic duodenosis: aetiology and long-term response to specific treatment. 2012; Dig Liver Dis 44: 643–8.
  10. Kakar S, Nehra V, Murray JA, Dayharsh GA, Burgart LJ. Significance of intraepithelial lymphocytosis in small bowel biopsy samples with normal mucosal architecture. Am J Gastroenterol 2003; 98:2027–33.
  11. Husby S, Koletzko S, Korponay-Szabó IR, Mearin ML, Phillips A, Shamir R. European Society for Pediatric Gastroenterology, Hepatology, and Nutrition guidelines for the diagnosis of coeliac disease. J Pediatr Gastroenterol Nutr. 2012;54:136-60
  12. Saborido R, Martinón N, Regueiro A, Crujeiras V, Eiras P, Leis R. Intraepithelial lymphocyte immunophenotype: a useful tool in the diagnosis of celiac disease. J Physiol Biochem. 2018 ;74:153-8.
  13. Eiras P, Roldán E, Camarero C, Olivares F, Bootello A, Roy G. Flow Cytometry Description of a Novel CD32/CD71 Intraepithelial Lymphocyte Subset in Human Duodenal Biopsies: Potential Diagnostic Value in Coeliac Disease. Cytometry. 1998 15;34:95-102.
  14. Leon F. Flow cytometry of intestinal intraepithelial lymphocytes in celiac disease. J Immunol Methods 2011; 363: 177–86
  15. Camarero C, Eiras P, Asensio A, Leon F, Olivares F, Escobar H, Roy G. Intraepithelial lymphocytes and coeliac disease: permanent changes in CD3-/CD7+ and T cell receptor gammadelta subsets studied by flow cytometry. Acta Paediatr. 2000; 89:285-90.
  16. Halstensen T.S, Scott H, Fausa O, Brandtzaeg, P et al. Gluten stimulation of coeliac mucosa in vitro induces activation (CD25) of lamina propria CD4+ T cells and macrophages but no crypt-cell hyperplasia. Scand. J. Immunol 1993; 38: 581-90
  17. Schuppan D. Current concepts of celiac disease pathogenesis. Gastroenterology 2000; 119:234-42
  18. Carton J, Byrne, B, Madrigal-Estebas, L, O'Donoghue, DP, O'Farrelly C. CD4+ CD8+ human small intestinal T cells are decreased in coeliac patients, with CD8 expression downregulated on intra-epithelial T cells in the active disease. Eur J. Gastroenterol. Hepatol 2004. 16: 961-8
  19. Holm K, Maki M, Savilahti E, Lipsanen V, Laippala P, Koskimies S. Intraepithelial gamma delta T-cell-receptor lymphocytes and genetic susceptibility to coeliac disease. Lancet 1992; 339:1500-3.
  20. Spencer J, MacDonald TT, Diss TC, Walker-Smith JA, Ciclitira PJ, Isaacson P. Changes in intraepithelial lymphocyte subpopulations in coeliac disease and enteropathy associated T cell lymphoma (malignant histiocytosis of the intestine). Gut 1989; 30:339-46
  21. Olivencia P, Cano A, Martín MA, León F, Roy G, et al. Adult celiac disease and intraepithelial lymphocytes. New options for diagnosis? Gastroenterol Hepatol 2008; 31: 555–9.
  22. Fernández-Bañares F, Carrasco A, García-Puig R, Rosinach M, González C, Alsina M et al. Intestinal Intraepithelial Lymphocyte Cytometric Pattern Is More Accurate than Subepithelial Deposits of Anti-Tissue Transglutaminase IgA for the Diagnosis of Celiac Disease in Lymphocytic Enteritis. PLoS One. 2014 10;9(7):e101249.
  23. Calleja S, Vivas S, Santiuste M, Arias L, Hernando M, Nistal E et al. Dynamics of non-conventional intraepithelial lymphocytes-NK, NKT, and cd T-in celiac disease: relationship with age, diet, and histopathology. Dig Dis Sci 2011; 56: 2042–9.
  24. Kokkonen J, Holm K, Karttunen TJ, Maki M. Children with untreated food allergy express a relative increment in the density of duodenal gammadelta+ T cells. Scand J. Gastroenterol 2000; 35, 1137-42
  25. León F, Sánchez L, Camarero C, Roy G. Cytokine production by intestinal intraepithelial lymphocyte subsets in celiac disease. Dig Dis Sci. 2005;50:593-600
  26. Kutlu T, Brousse N, Rambaud C, Le Deist F, Schmitz J, Cerf-Bensussan N. Numbers of T cell receptor (TCR) alpha beta+ but not of TcR gamma delta+ intraepithelial lymphocytes correlate with the grade of villous atrophy in coeliac patients on a long term normal diet. Gut 1993; 34: 208–14.
  27. Savilahti E, Arato A, Verkasalo M. Intestinal gamma/delta receptor bearing T lymphocytes in celiac disease and inflammatory bowel diseases in children. Constant increase in celiac disease. Pediatr Res 1990; 28: 579–81.
  28. Halstensen TS, Scott H, Brandtzaeg P. Intraepithelial T cells of the TcR gamma/delta+CD82 and V delta 1/J delta 1+ phenotypes are increased in coeliac disease. Scand J Immunol 1993; 30: 665–72.
  29. Mäki M, Holm K, Collin P, Savilahti E. Increase in gamma/delta T cell receptor bearing lymphocytes in normal small bowel mucosa in latent coeliac disease. Gut 1991; 32: 1412–4.
  30. Raki M, Fallang LE, Brottveit M, Bergseng E, Quarsten H, Lundin KE, Sollid LM. Tetramer visualization of gut-homing gluten-specific T cells in the peripheral blood of celiac disease patients. Proc. Natl. Acad 2007 Sci. USA 104, 2831-6
  31. Brottveit M, Ráki M, Bergseng E, Fallang LE, Simonsen B, Løvik A et al. Assessing possible celiac disease by an HLA-DQ2-gliadin Tetramer Test. Am J Gastroenterol. 2011;106:1318-24.
  32. Sarna VK, Lundin KEA, Mørkrid L, Qiao SW, Sollid LM, Christophersen A. HLA-DQ-Gluten Tetramer Blood Test Accurately Identifies Patients With and Without Celiac Disease in Absence of Gluten Consumption. Gastroenterology. 2018;154:886-96
  33. López-Palacios N, Pascual V, Castaño M, Bodas A, Fernández-Prieto M, Espino-Paisán L et al. Evaluation of T cells in blood after a short gluten challenge for coeliac disease diagnosis. Dig Liver Dis. 2018;50:1183-8.
  34. Capparelli, R., Ventimiglia, I., Longobardo, L., Iannelli, D. Quantification of gliadin levels to the picogram level by flow cytometry. Cytom. 2005. A 63, 108
  35. Tokuda R, Nagao M, Hiraguchi Y, Hosoki K, Matsuda T, Kouno K et al.  Antigen-induced expression of CD203c on basophils predicts IgE-mediated wheat allergy. Allergol Int 2009; 58, 193-9.
  36. Verbeek WH, von Blomberg BM, Coupe VM, Daum S, Mulder CJ, Schreurs MW. Aberrant T-lymphocytes in refractory coeliac disease are not strictly confined to a small intestinal intraepithelial localization. Cytometry B Clin Cytom. 2009; 76:367-74
  37. Mulder CJ, Wahab PJ, Moshaver B, Meijer JW Refractory coeliac disease: a window between coeliac disease and enteropathy associated T cell lymphoma. Scand J Gastroenterol Suppl. 2000; (232):32-7.
  38. Cellier C, Delabesse E, Helmer C, Patey N, Matuchansky C, Jabri B et al. Refractory sprue, coeliac disease, and enteropathy-associated T-cell lymphoma. French Coeliac Disease Study Group. Lancet. 2000 15; 356(9225):203-8.
  39. Malamut G, Cellier C. Refractory Celiac Disease. In: Buchman AL (ed). Celiac disease. Gastroenterol Clin N Am 2019; 48: 137-45