The clinical picture of celiac disease has changed over recent years and symptoms are now recognized as being extremely diverse.
Typical or classic symptoms of celiac disease include altered bowel habits, weight loss, fatigue, abdominal pain and bloating, nausea and growth failure (in children). However, a range of additional symptoms or medical complications may also indicate the presence of celiac disease – including; iron deficiency anemia, osteoporosis, amenorrhea, vitamin and mineral deficiencies, unexplained infertility, neurological disturbances, thyroid and liver diseases [1,2].
Clinical Presentation 
- Abdominal bloating or distention
- Chronic diarrhea
- Weight loss
- Failure to thrive/short stature
- Abdominal pain
- Mouth Sores
- Profuse vomiting
- Anemia (iron, vitamin B12, folic acid)
- Dental enamel defects
- Aphthous ulcers
- Dermatitis Herpetiformis/skin manifestation and rash
- Short stature
- Delayed puberty
- Vitamin D deficiency
- Fertility disorders
- Abnormal liver enzymes
- Chronic fatigue
- Head aches
- Mood and psychiatric changes
Silent Celiac Disease
Positive antibodies and positive biopsy without overt gastrointestinal or extraintestinal symptoms
Silent celiac is often found when screening high risk groups such as first degree relatives, individuals with Type 1 diabetes or Down syndrome.
Latent Celiac Disease
Positive or negative antibodies with negative biopsy
This group would also include those with the genetic markers (HLA-DQ2 or HLA-DQ8) but without positive antibodies or biopsy.
High risk groups such as immediate family members, individuals with Type 1 diabetes would fall into the category of negative antibodies and negative biopsy until celiac disease manifests itself.
Dermatitis herpetiformis (DH) is the skin manifestation of celiac disease triggered by the ingestion of gluten. It is characterised by the appearance of a patchy, itchy rash and small blisters, most commonly found bilaterally on the elbows, knees, buttocks and scalp. Unlike the gastrointestinal symptomatic manifestation of celiac disease, Dermatitis Herpetiformis is more common in men than in women. The overall population prevalence of 1:3,300. Even though less than 10% of patients with Dermatitis Herpetiformis have gut symptoms most have total or subtotal villous atrophy upon histological examination . As in individuals presenting with the gastrointestinal symptoms of celiac disease, virtually all patients with Dermatitis Herpetiformis carry the HLA DQ2/DQ8 alleles.
Treatment of Dermatitis Herpetiformis
A strict, life-long gluten free diet is the mainstay of treatment for this condition. In the first month after diagnosis. Several drugs including Dapsone, sulfones or steroids, can be used to help decrease symptoms and inflammation. More than 70% of patients following a strict gluten free diet are able to slowly reduce their drug dose over time .
- James, S.P.(2005). National Institutes of Health consensus development conference statement on celiac disease, June 28-30, 2004. Gastroenterology; 128(4 Pt 2); S1 9.
- Celiac disease. Green PH, Lebwohl B, Greywoode R. J Allergy Clin Immunol. 2015 May;135(5):1099-106; quiz 1107. doi: 10.1016/j.jaci.2015.01.044. Review
- Fry L, Seah PP, Harper PG et al.The small intestine in dermatitis herpetiformis. J Clin Pathol 1974; 27:817-24
- Fry L. Leonard JN, Swain F et al. Long term follow up of dermatitis herpetiformis with and without dietary gluten withdrawal. Br J Dermatol 1982; 107:631-40